Persistent, refractory, and biphasic anaphylaxis: A multidisciplinary Delphi study

Biphasic anaphylaxis to gemifloxacin

Anaphylaxis have been documented as adverse effects of ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, and moxifloxacin. However resistant and biphasic anaphlylactic reactions to gemifloxacin have not been reported to date. Management of severe anaphylaxis in the elderly can be complicated by concurrent medications such as beta (β) adrenergic, alpha (α) adrenergic blockers and angiotensin-...

Biphasic Anaphylaxis: A Review of the Incidence, Characteristics and Predictors

While it has been recognized for over a quarter century that anaphylactic reactions have the potential to follow a biphasic course, reports on the incidence of biphasic anaphylaxis are conflicting, and the search for reliable predictive factors of such responses has been challenging. Further adding to the complexity of this clinical entity are the widely variable durations of the asymptomatic w...

Biphasic anaphylaxis: a systematic review of the literature

Methods A systematic review was performed identifying case reports and retrospective and prospective studies reporting biphasic allergic reactions. “Biphasic anaphylaxis” (BA) was defined as an anaphylactic reaction consisting of 2 distinct phases separated by at least 1 hour, with both phases meeting internationally recognized diagnostic criteria for anaphylaxis. Pediatric and adult cases were...

Severe biphasic anaphylaxis to bigarreau cherry in a child.

Key components of anaphylaxis management plans: consensus findings from a national electronic Delphi study

OBJECTIVES There is no international consensus on the components of anaphylaxis management plans and responsibility for their design and delivery is contested. We set out to establish consensus among relevant specialist and generalist clinicians on this issue to inform future randomized controlled trials. DESIGN A two-round electronic Delphi study completed by a 25-person, multidisciplinary e...